Aretha Franklin, the undisputed “Queen of Soul” who sang with matchless style on such classics as “Think,” ”I Say a Little Prayer” and her signature song, “Respect,” and stood as a cultural icon around the globe, has died at age 76 from pancreatic cancer.

Publicist Gwendolyn Quinn told The Associated Press through a family statement that Franklin died Thursday at 9:50 a.m. at her home in Detroit.

The family added: “In one of the darkest moments of our lives, we are not able to find the appropriate words to express the pain in our heart. We have lost the matriarch and rock of our family. The love she had for her children, grandchildren, nieces, nephews, and cousins knew no bounds.”

The statement continued: “We have been deeply touched by the incredible outpouring of love and support we have received from close friends, supporters and fans all around the world. Thank you for your compassion and prayers. We have felt your love for Aretha and it brings us comfort to know that her legacy will live on. As we grieve, we ask that you respect our privacy during this difficult time.”

Funeral arrangements will be announced in the coming days.

Franklin, who had battled undisclosed health issues in recent years, had in 2017 announced her retirement from touring.

A professional singer and accomplished pianist by her late teens, a superstar by her mid-20s, Franklin had long ago settled any arguments over who was the greatest popular vocalist of her time. Her gifts, natural and acquired, were a multi-octave mezzo-soprano, gospel passion and training worthy of a preacher’s daughter, taste sophisticated and eccentric, and the courage to channel private pain into liberating song.

She recorded hundreds of tracks and had dozens of hits over the span of a half-century, including 20 that reached No. 1 on the R&B charts. But her reputation was defined by an extraordinary run of top 10 smashes in the late 1960s, from the morning-after bliss of “(You Make Me Feel Like) A Natural Woman,” to the wised-up “Chain of Fools” to her unstoppable call for “Respect.”

Her records sold millions of copies and the music industry couldn’t honor her enough. Franklin won 18 Grammy awards. In 1987, she became the first woman inducted into the Rock and Roll Hall of Fame.

Clive Davis, the music mogul who brought her to Arista Records and helped revive her career in the 1980s, said he was “devastated” by her death.

“She was truly one of a kind. She was more than the Queen of Soul. She was a national treasure to be cherished by every generation throughout the world,” he said in a statement. “Apart from our long professional relationship, Aretha was my friend. Her loss is deeply profound and my heart is full of sadness.”

Smokey Robinson, who grew up with her in Detroit, said: “This morning my longest friend in this world went home to be with our father. I will miss her so much but I know she’s at peace.”

Fellow singers bowed to her eminence and political and civic leaders treated her as a peer.

The Rev. Martin Luther King Jr. was a longtime friend, and she sang at the dedication of King’s memorial, in 2011.

She performed at the inaugurations of Presidents Bill Clinton and Jimmy Carter, and at the funeral for civil rights pioneer Rosa Parks. Clinton gave Franklin the National Medal of Arts. President George W. Bush awarded her the Presidential Medal of Freedom, the nation’s highest civilian honor, in 2005.

Bill and Hillary Clinton issued a statement mourning the loss of their friend and “one of America’s greatest treasures.”

“For more than 50 years, she stirred our souls. She was elegant, graceful, and utterly uncompromising in her artistry. Aretha’s first music school was the church and her performances were powered by what she learned there. I’ll always be grateful for her kindness and support, including her performances at both my inaugural celebrations and for the chance to be there for what sadly turned out to be her final performance last November at a benefit supporting the fight against HIV/AIDS.”

Franklin’s best-known appearance with a president was in January 2009, when she sang “My Country ‘tis of Thee” at President Barack Obama’s inauguration. She wore a gray felt hat with a huge, Swarovski rhinestone-bordered bow that became an internet sensation and even had its own website.

In 2015, she brought Obama and others to tears with a triumphant performance of “Natural Woman” at a Kennedy Center tribute to the song’s co-writer, Carole King.

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